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A Common Nuclear Factor That Binds to the Transcriptional Control Regions of Ribosomal Protein L5 and 5S rRNA Genes

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
194
Issue
3
Identifiers
DOI: 10.1006/bbrc.1993.1939
Disciplines
  • Biology

Abstract

Abstract We have examined the binding of chicken nuclear protein to the promoter regions of chicken ribosomal protein L5 and 5S rRNA genes. A nuclear protein was shown to bind to similar sequences in both promoter regions of the L5 gene (−36 to −21) and the internal control region of 5S rRNA gene (56 to 71). Its molecular mass was estimated to be 34 kDa. Competition gel mobility assay showed that the protein is different from the TATA-box binding protein (TBP). The protein may play a role in a transcriptional coordination of the two genes transcribed by different polymerases, RNA polymerase II and III.

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