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One-pot multicomponent synthesis of unsymmetrical polyhydroquinoline derivatives with 1,1′-butylenebispyridinium hydrogen sulfate as an efficient, halogen-free and reusable Brönsted ionic liquid catalyst

Authors
Journal
Chinese Journal of Catalysis
1872-2067
Publisher
Elsevier
Identifiers
DOI: 10.1016/s1872-2067(14)60087-5
Keywords
  • Unsymmetric Polyhydroquinolines
  • Brönsted Acidic Ionic Liquid
  • Ultrasonication
  • Multicomponent
  • Solvent-Free

Abstract

Abstract 1,1′-Butylenebispyridinium hydrogen sulfate is an efficient, halogen-free and reusable Brönsted ionic liquid catalyst for the synthesis of ethyl-4-aryl/heteryl-hexahydro-trimehtyl-5-oxoquinoline-3-carboxylates by the one-pot condensation of dimedone, aryl/heteryl aldehydes, ethyl acetoacetate, and ammonium acetate under solvent-free conditions. This method has the advantages of high yield, clean reaction, simple methodology, and short reaction time. The ionic liquid can be recycled five times without significant loss of the catalytic activity.

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