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Three-day course of antibiotics as effective as seven-day course for older women with urinary tract infection

Journal
Evidence-based Healthcare and Public Health
1744-2249
Publisher
Elsevier
Publication Date
Volume
8
Issue
5
Identifiers
DOI: 10.1016/j.ehbc.2004.08.014
Keywords
  • Urinary Tract Infection
  • Older Women
  • Antibiotic Treatment Duration
  • Randomised Controlled Trail
Disciplines
  • Design

Abstract

Summary Question Are antibiotics for three days as effective as antibiotics for seven days in older women with urinary tract infection? Study design Double-blind randomised controlled trial. Main results There was no significant difference in bacterial eradication rates between groups at two days after completion of treatment (3 day 98% vs. 7 day 93%, p = 0.16 ). Similarly, there was no significant difference in re-infection rates six weeks after treatment. Three-day antibiotics significantly reduced the mean number of adverse events compared with 7-day antibiotics (0.9 vs. 1.6 at 5 days and 1.2 vs. 2.1 at 9 days, both p = 0.001 ). Authors’ conclusions A shorter course of antibiotics was as effective as a longer course in older women with urinary tract infection, and was better tolerated.

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