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Caesarean section at term: the relationship between neonatal respiratory morbidity and microviscosity in amniotic fluid

Authors
Journal
European Journal of Obstetrics & Gynecology and Reproductive Biology
0301-2115
Publisher
Elsevier
Volume
169
Issue
2
Identifiers
DOI: 10.1016/j.ejogrb.2013.05.003
Keywords
  • Caesarean Section
  • Respiratory Morbidity
  • Surfactant
  • Microviscosity
  • Fluorescence Polarisation
Disciplines
  • Biology
  • Design

Abstract

Abstract Objectives The incidence of neonatal respiratory morbidity following an elective caesarean section is 2–3 times higher than after a vaginal delivery. The microviscosity of surfactant phospholipids, as measured with fluorescence polarisation, is linked with the functional characteristics of fetal surfactant and thus fetal lung maturity, but so far this point has received little attention in new-borns at term. The aim of the study is to evaluate the correlation between neonatal respiratory morbidity and amniotic microviscosity (Fluorescence Polarisation Index) in women undergoing caesarean section after 37 weeks’ gestation. Study design The files of 136 women who had undergone amniotic microviscosity studies during elective caesarean deliveries at term were anonymised. Amniotic fluid immaturity (AFI) was defined as a Fluorescence Polarisation Index higher than 0.335. Results Respiratory morbidity was observed in 10 babies (7.3%) and was independently associated with AFI (OR: 6.11 [95% CI, 1.20–31.1] with p=0.029) and maternal body mass index (OR: 1.12 [95% CI, 1.02–1.22] with p=0.019). Gestational age at the time of caesarean delivery was inversely associated with AFI (odds ratio, 0.46 [95% confidence interval, 0.29–0.71], p<0.001), especially before 39 weeks, and female gender was associated with an increased risk (odds ratio, 3.29 [95% confidence interval, 1.48–7.31], p=0.004). Conclusions AFI assessed by amniotic microviscosity was significantly associated with respiratory morbidity and independently correlated with shorter gestational age especially before 39 weeks. This finding provides a physiological rationale for recommending delaying elective caesarean section delivery until 39 weeks of gestation to decrease the risk for respiratory morbidity.

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