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Fixing clearance as early as lead optimization using high throughputin vitroincubations in combination with exact mass detection and automatic structure elucidation of metabolites

Authors
Journal
Drug Discovery Today Technologies
1740-6749
Publisher
Elsevier
Volume
10
Issue
1
Identifiers
DOI: 10.1016/j.ddtec.2012.09.009
Disciplines
  • Chemistry
  • Design

Abstract

New enabling MS technologies have made it possible to elucidate metabolic pathways present in ex vivo (blood, bile and/or urine) or in vitro (liver microsomes, hepatocytes and/or S9) samples. When investigating samples from high throughput assays the challenge that the user is facing now is to extract the appropriate information and compile it so that it is understandable to all. Medicinal chemist may then design the next generation of (better) drug candidates combining the needs for potency and metabolic stability and their synthetic creativity. This review focuses on the comparison of these enabling MS technologies and the IT tools developed for their interpretation.

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