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Positive and negative regulators of transforming growth factor beta 1/bone morphogenetic protein pathways are constitutively expressed in mesangial cells

Authors
Journal
Critical Care
1364-8535
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
7
Identifiers
DOI: 10.1186/cc2315
Keywords
  • Meeting Abstract
Disciplines
  • Biology
  • Medicine
  • Pharmacology

Abstract

S1 Available online http://ccforum.com/supplements/7/S3 Critical Care Volume 7 Suppl 3, 2003 Second International Symposium on Intensive Care and Emergency Medicine for Latin America São Paulo, Brazil, 25–28 June 2003 Published online: 25 June 2003 These abstracts are online at http://ccforum.com/supplements/7/S3 © 2003 BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X) CARDIOLOGY P1 Impact of peroperative administration of steroid over inflammatory response and pulmonary dysfunction following cardiac surgery HTF Mendonça Filho1,2, LAA Campos1, RV Gomes1, FES Fagundes1, EM Nunes1, R Gomes2, F Bozza2, PT Bozza2, HC Castro-Faria-Neto2 1Surgical Intensive Care Unit, Hospital Pró-Cardíaco, Rio de Janeiro, RJ, Brazil; 2Laboratory of Immunopharmacology, Department of Pharmacodymamics, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil Critical Care 2003, 7(Suppl 3):P1 (DOI 10.1186/cc2197) Introduction Cardiac surgery with cardiopulmonary bypass (CPB) is a recognized trigger of systemic inflammatory response, usually related to postoperative acute lung injury (ALI). As an attempt to dampen inflammatory response, steroids have been perioperatively administered to patients. Macrophage migration inhibitory factor (MIF), a regulator of the endotoxin receptor, is implicated in the pathogenesis of ALI. We have previously detected peak circulating levels of MIF, 6 hours post CPB. Experimental data have shown that steroids may induce MIF secretion by mononuclear cells. This study aims to correlate levels of MIF assayed 6 hours post CPB to the intensity of postoperative pulmonary dysfunction, analysing the impact of perioperative steroid administration. Methods We included patients submitted to cardiac surgery with CPB, electively started in the morning, performed by the same team under a standard technique except for the addition of methyl- prednisolone (15 mg/kg) to the CPB priming solution for patients from group MP (n = 37), but not for the remaining patients — group NS (n =

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