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Sites of Acetylation of Sickle Cell Hemoglobin by Aspirin

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PMC
Keywords
  • Biological Sciences: Biochemistry

Abstract

Aspirin acetylates a variety of sites on both the α and β chains of hemoglobin S. Nevertheless, the vast majority of acetyl groups become attached to three loci: βLys 59, βLys 144, and αLys 90. These observations reveal some molecular details of this transacylation reaction and suggest interesting possibilities for its extension to other acylsalicylates with a variety of different structures.

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