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Prediction of Human Intestinal Absorption by GA Feature Selection and Support Vector Machine Regression

Authors
Journal
International Journal of Molecular Sciences
1422-0067
Publisher
MDPI AG
Publication Date
Volume
9
Issue
10
Identifiers
DOI: 10.3390/ijms9101961
Keywords
  • Article

Abstract

QSAR (Quantitative Structure Activity Relationships) models for the prediction of human intestinal absorption (HIA) were built with molecular descriptors calculated by ADRIANA.Code, Cerius2 and a combination of them. A dataset of 552 compounds covering a wide range of current drugs with experimental HIA values was investigated. A Genetic Algorithm feature selection method was applied to select proper descriptors. A Kohonen's self-organizing Neural Network (KohNN) map was used to split the whole dataset into a training set including 380 compounds and a test set consisting of 172 compounds. First, the six selected descriptors from ADRIANA.Code and the six selected descriptors from Cerius2 were used as the input descriptors for building quantitative models using Partial Least Square (PLS) analysis and Support Vector Machine (SVM) Regression. Then, another two models were built based on nine descriptors selected by a combination of ADRIANA.Code and Cerius2 descriptors using PLS and SVM, respectively. For the three SVM models, correlation coefficients (r) of 0.87, 0.89 and 0.88 were achieved; and standard deviations (s) of 10.98, 9.72 and 9.14 were obtained for the test set.

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