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The Ever-Lengthening Arm of p53

Authors
Journal
Cancer Cell
1535-6108
Publisher
Elsevier
Publication Date
Volume
14
Issue
2
Identifiers
DOI: 10.1016/j.ccr.2008.07.012
Disciplines
  • Biology

Abstract

p53 is a pivotal bulwark against cancer, but exactly how it suppresses tumors remains elusive, in part because it modulates such diverse biological processes via so many downstream pathways. In a recent issue of Cell, Godar et al. (2008) now identify another string to p53's anticancer bow—repression of the CD44 cell-surface glycoproteins that coordinate many attributes of tumor progression.

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