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The genetic influences on oxycodone non-responsiveness in a variety of experimental pain stimulations in healthy volunteers

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  • Medicine

Abstract

CongressName SPECIAL LECTURE AND PLENARY ABSTRACTS – No. 1 – 6 TOPICAL SEMINAR ABSTRACTS – No. 7 – 41 POSTER ABSTRACTS – No. 42 – 1133 (Poster abstracts are listed in orderof the scientific programme so do not run in numerical sequence) 1 Ulf Lindblom Special Lecture: BASIC SCIENCE AND MECHANISMS OF VISCERAL PAIN F. Cervero The Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada Visceral pain is an important component of the normal sensory repertoire of all human beings and a prominent symptom of many clinical conditions. Visceral pain is also one of the most frequent reasons for patients to seek medical attention. However, many practitioners regard visceral pain as only a symptom of the underlying disease that will go away once the disease is cured. Also, much of what we know about the basic mechanisms of pain derives from experimental studies of somatic nociception. Even chronic pain models are generally based on inflammatory lesions of the skin, muscles or joints or on peripheral nerve injuries and therefore pain of internal origin, or visceral pain, is a subject of lesser interest. Yet, it is now quite clear that different forms of pain are mediated by different neurological mechanisms so that it is no longer possible to maintain a view of the pain system as a simple alarm device with a single, unique organization. The study of visceral pain can offer insights into the workings of the brain that may be complementary to what we know from studies of somatic or neuropathic pain. Also, the treatment of some forms of visceral pain is now oriented more towards the neurological system that mediates the pain than towards the underlying disease of the visceral organ. This is particularly relevant in conditions such as the irritable bowel syndrome where treatment is often directed to the nervous system rather than to the gastrointestinal tract. Visceral nociception generates increases in pain sensitivity in locations rem

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