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Pulmonary Dosimetry of Nitrogen Dioxide in Animals and Man

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Identifiers
DOI: 10.1016/b978-0-444-42127-2.50038-5
Disciplines
  • Chemistry
  • Mathematics
  • Medicine

Abstract

ABSTRACT Using a general mathematical model formulation for the transport of gases in the lungs, we studied the regional pulmonary deposition of nitrogen dioxide (NO2) in man, rabbits, guinea pigs, and rats. The model formulation utilizes lung morphometric data and includes parameters reflecting physicochemical properties of NO2, ventilatory patterns, and chemical reactions of NO2 with components of tne protective layer linings of the lungs. Sensitivity of model predicted doses to changes in some of the above parameters are discussed as well as qualitative comparisons between animals and man in the shape of the dose curves.

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