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Pain as a symptom of peripheral nerve sheath tumors: clinical significance and future therapeutic directions

Authors
Journal
Journal of Brachial Plexus and Peripheral Nerve Injury
1749-7221
Publisher
Thieme Publishing Group
Publication Date
Volume
3
Issue
1
Identifiers
DOI: 10.1186/1749-7221-3-6
Keywords
  • Review
Disciplines
  • Medicine

Abstract

Tumors arising from the supporting cells of peripheral nerve sheaths are relatively uncommon neoplasms, and as such many clinicians are unfamiliar with the details of their presentation, diagnosis and management. Further, little is known regarding the pathogenesis of these tumors, how they cause symptoms, and how to treat these symptoms. One classic symptom of peripheral nerve tumors is pain, however there has been little formal discussion regarding the significance of pain in this setting. Here we present a brief review of the clinical significance of pain, its relevance in pre-operative planning for the treatment of these tumors, and what is known regarding the molecular mechanisms of pain generation by these tumors.

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