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Synthesis and metabolism of prostaglandins E2, F2αand D2by the rat gastrointestinal tract. Stimulation by a hypertonic environment in vitro

Authors
Journal
Prostaglandins & Other Lipid Mediators
0090-6980
Publisher
Elsevier
Publication Date
Volume
15
Issue
5
Identifiers
DOI: 10.1016/0090-6980(78)90141-7

Abstract

Abstract Whole cell preparations of rat stomach corpus, jejunum, and colon were incubated and the released prostaglandin E 2 (PGE 2), PGF 2α, PGD 2, 15 keto-13,14 dihydro PGE 2, and 15 keto-13,14 dihydro PGF 2α were measured by combined gas chromatography-mass spectrometry. All regions made PGD 2 and possessed a high capacity for producing 15 keto-13,14 dihydro derivatives of both PGE 2 and PGF 2α. Hypertonic sucrose solutions resulted in concentration-dependent increases in prostaglandin release, particularly of PGE 2 and its metabolite. It is suggested that PG's may play a role in the local effects of luminal hyperosomolarity on digestive tract functions.

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