Affordable Access

Publisher Website

Antibiotic susceptibility profiles of oral pathogens

International Journal of Antimicrobial Agents
DOI: 10.1016/j.ijantimicag.2012.07.004
  • Antibiotics
  • Mic
  • Periodontal Pathogens
  • Medicine


Abstract Periodontitis is a bacterial disease that can be treated with systemic antibiotics. The aim of this study was to establish the antibiotic susceptibility profiles of five periodontal pathogens to six commonly used antibiotics in periodontics. A total of 247 periodontal bacterial isolates were tested for susceptibility to the six antibiotics using the Etest method. MIC50 and MIC90 values (minimum inhibitory concentrations for 50% and 90% of the organisms, respectively) were calculated. Both European Committee on Antimicrobial Susceptibility Testing (EUCAST) and Clinical and Laboratory Standards Institute (CLSI) breakpoints were used in the study to interpret results. β-Lactamase production was tested when amoxicillin resistance was found. MIC90 values of the anaerobic bacteria were all well below breakpoint values, except for three isolates of Prevotella intermedia and one isolate of Fusobacterium nucleatum that were resistant to amoxicillin (CLSI breakpoints); these isolates were β-lactamase-positive. Two isolates of the capnophilic Aggregatibacter actinomycetemcomitans appeared to be amoxicillin-resistant but failed to show β-lactamase activity. Comparison with a previous study from The Netherlands showed minor differences in susceptibility profiles, but the MIC90 values of A. actinomycetemcomitans for amoxicillin, clindamycin, azithromycin and tetracycline were higher. Geographical differences in the susceptibility profiles of Porphyromonas gingivalis and A. actinomycetemcomitans between European countries were noted. Comparison of European susceptibility profiles with that of a South American country (Colombia) revealed a much higher resistance in the latter. Owing to these differences in susceptibility profiles, it is of concern to regularly perform surveillance studies on antibiotic resistance.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Pathogens and antibiotic susceptibility profiles i...

on East African medical journal October 1992

Susceptibility of female pelvic pathogens to oral...

on American Journal of Obstetrics... May 1991

Susceptibility of female pelvic pathogens to oral...

on American Journal of Obstetrics... Jan 01, 1991
More articles like this..