Abstract The clinicopathologic staging of bladder cancer is the main prognostic aid in superficial tumor since it has close relation to the degree of differentiation of the tumor and the observed degree of its progression in the 238 cases of this series. The survival rate of the patients was related to the depth of penetration and degree of histologic differentiation of the tumor. Thus both the stage and the grade of the tumor together had prognostic value. Primary clinical staging correlated well with the size of the initial lesion, but not with the location, number of primary lesions or subsequent recurrences, or time of the appearance of progression of the primary lesion. Almost one third of the patients with superficial bladder cancer died from bladder cancer. Two thirds of the cases with known pathologic stage at autopsy showed extravesical extension of the lesion. Prior external radiation to the superficial tumors apparently did not affect progression of the primary lesion.