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Therapeutics for depression and anxiety disorders

Authors
Journal
Drug Discovery Today Therapeutic Strategies
1740-6773
Publisher
Elsevier
Publication Date
Volume
1
Issue
1
Identifiers
DOI: 10.1016/j.ddstr.2004.08.012
Disciplines
  • Biology
  • Medicine

Abstract

Section Editor: Ray Hill—Neuroscience Research, Merck, Sharp & Dohme Ltd, UK Depression and anxiety are conditions for which a substantial part of the population will need treatment during their lifetime but we do not yet have drugs that work in all patients, nor do we have a full understanding of the mechanism of those empirically discovered drugs that are used currently. This review deals with the current state of research in this important area and outlines the three main themes being followed: (i) the search for an understanding of the mechanisms by which current antidepressant drugs work, especially the possibility of an effect on neuroregeneration; (ii) the move towards modulation of stress-related brain circuitry for treatment; and (iii) the introduction of drug discovery strategies derived from genomics. The author has been a leader in this field for many years and was one of the first to conduct clinical studies with the CRF-receptor antagonists in the experimental treatment of depression. He has been a strong proponent of the relationship between stress and depression and recently his research has focused on the genetic basis of neuropsychiatric disorders.

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