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A case of lung cancer associated with granulocytosis and production of colony-stimulating activity by the tumour.

British Journal of Cancer
Nature Publishing Group
Publication Date
  • Research Article
  • Medicine


Br. J. Cancer (1980) 41, 980 Short Communication A CASE OF LUNG CANCER ASSOCIATED WITH GRANULOCYTOSIS AND PRODUCTION OF COLONY-STIMULATING ACTIVITY BY THE TUMOUR T. SUDA*, Y. MIURA*, H. MIZOGUCHI*, K. KUBOTA* AND F. TAKAKUt From the *Division of Haemopoiesis, Institute of Haemnatology and tFirst Department of Medicine, Jichi Medical School, Minamikawachi-machi, Tochigi-ken, Japan Received 30 October 1979 PROMINENT GRANULOCYTOSIS with no evidence of significant infections has been observed in some patients with non- haematological malignancies (Hughes & Higley, 1952). Factors stimulating granu- lopoiesis produced by such tumours have been detected by several authors (Robin- son, 1974; Asano et al., 1977; Niho & Kimura, 1978; Sato et al., 1979). Asano et al. (1977) first reported that human lung cancer transplanted into nude mice actu- ally caused nmarked granulocytosis. In such cases, there are various problems with assay methods for colony-stimulating activity (CSA), such as differences in the response to CSA of murine and human marrow cells (Lind et al., 1974). We investigated a patient with squamous-cell carcinoma of the lung who developed marked neutrophilic granulo- cytosis, in a search for CSA in serum and tumour tissue using human marrow cells as the target. A 56-year-old Japanese woman was admitted to the Jichi Medical School Hospital because of a large tumour shadow and an accumulation of pleural fluid in the right lung field. The haemo- globin concentration was 12-0 g/dl; the WBC count was 64,400/mm3 with 9000 mature neutrophils, 2-5% eosinophils, 200% monocytes and 5.500 lymphocytes, and the platelet count was 152,000/mm3. Accepte(d 23 January 1980 The neutrophil alkaline phosphatase score was 484 (Tomonaga's method; the full score is 500 and the normal range 170-350). Marrow aspiration from the sternunm revealed hypercellularity with a marked myeloid hyperplasia. Philadelphia chromosome was absent and bacterio- logical examinations of the blood, urine and sputum always p

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