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Regulation of the cytosolic free calcium concentration by Na+spikes in immature cerebellar neurons with N-methyl-d-aspartate receptors

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
527
Issue
1
Identifiers
DOI: 10.1016/0006-8993(90)91075-r
Keywords
  • Cerebellar Neuron
  • Cytosolic Free Calcium
  • Fura-2 Microfluorometry
  • N-Methyl-D-Aspartate
  • Tetraethylammonium

Abstract

Abstract N-Methyl- d-aspartate and glycine increased the cytosolic free calcium concentration ([Ca] in) in medium-sized cerebellar neurons. Spontaneous changes in [Ca] in were occasionally observed in NMDA-responsive cells, but large increases in [Ca] in were triggered only through depolarizations by adding veratridine or K + channel blockers in every cell examined. The [Ca] in increase was suppressed by voltage-dependent Na + and Ca 2+ channel blockers and by an inhibitory transmitter (GABA), suggesting that the generation of Na + spikes is involved in the increase in [Ca] in.

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