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A case of IgD myeloma representing a missed biclonal paraproteinemia or isotype switch in a patient previously diagnosed with IgA–lambda myeloma

Authors
Journal
Clinica Chimica Acta
0009-8981
Publisher
Elsevier
Publication Date
Volume
425
Identifiers
DOI: 10.1016/j.cca.2013.08.004
Keywords
  • Multiple Myeloma
  • Igd
  • Biclonal Myeloma
  • Isotype Switch
  • Immunofixation
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Background Multiple myeloma is a clonal plasma cell neoplasm that is identified in the laboratory by a presence of a monoclonal immunoglobulin or increased plasma light chain levels. Methods The most commonly identified and tested immunoglobulins are IgA, IgG and IgM. Results Rare cases of multiple myeloma present with monoclonal IgD and IgE paraproteins. Conclusion We present a case of IgD myeloma diagnosed in a patient who had achieved partial remission from a previously diagnosed IgA myeloma, possibly representing a missed biclonal paraproteinemia or isotype switch after treatment.

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