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Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regions.

Authors
  • 1
Type
Published Article
Journal
BMC Genomics
1471-2164
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
13
Pages
566–566
Identifiers
DOI: 10.1186/1471-2164-13-566
PMID: 23102236
Source
Medline

Abstract

We identify the existence of EIs as a finer layer of epigenomic architecture within large heterochromatin domains. Their enrichment for CTCF sites and DNAse hypersensitive sites, as well as association with DMRs, suggest that EIs play an important role in normal epigenomic architecture and its disruption in disease.

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