Affordable Access

Publisher Website

Synthesis and characterization of lactobionic acid grafted pegylated chitosan and nanoparticle complex application

Authors
Journal
Polymer
0032-3861
Publisher
Elsevier
Publication Date
Volume
50
Issue
17
Identifiers
DOI: 10.1016/j.polymer.2009.06.076
Keywords
  • Chitosan
  • Methoxy Poly(Ethylene Glycol)
  • Lactobionic Acid
Disciplines
  • Chemistry

Abstract

Abstract A series of chemical modifications of chitosan were conducted by grafting a hydrophilic methoxy poly(ethylene glycol) (MPEG) and a target sugar molecule lactobionic acid (LA). The MPEG was grafted onto C6–OH position of chitosan, and the grafting degree was reduced for chitosan with high degree of depolymerization. The lactobionic acid was proposed to graft onto C2–NH 2 position of chitosan. The LA grafting ratio was dependent on pegylation degree of chitosan, where the flexibility and shielding effect of MPEG hindered LA grafting onto chitosan. The lactobionic acid grafted pegylated chitosan, DADP-CS-(O-MPEG)-( N-LA), successfully provoked DNA condensation into nanoparticle complexes due to electrostatic compaction. The presence of MPEG on DADP-CS-(O-MPEG)-( N-LA) played an important role on preventing nanoparticle aggregation.

There are no comments yet on this publication. Be the first to share your thoughts.