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Metabolism of 5-hydroxy-4-keto-valeric acid in the rat

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
40
Issue
3
Identifiers
DOI: 10.1016/0006-291x(70)90941-1

Abstract

Abstract Studies in vivo and in vitro were made of the metabolism of 5-hydroxy-4-keto-valeric acid HKV , which is formed by decarboxylation of 2-hydroxy-3-keto-adipate, the primary condensation product of the 2-ketoglutarate:glyoxylate carboligase reaction. Evidence is presented for the formation of 14C-aspartate, 14C-glutamate and 14C-delta-aminolevulinic acid when 14C-HKV is incubated with sonicated rat liver mitochondria. Formation of these products suggests that HKV may be converted to 2-keto-glutamate and delta-aminolevulinic acid via 4,5-dioxo-valerate. In vivo oxidation of 14C-HKV to 14CO 2 is also shown in the rat.

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