Affordable Access

Publisher Website

Differential and overlapping expression pattern of SOX2 and SOX9 in inner ear development

Gene Expression Patterns
Publication Date
DOI: 10.1016/j.gep.2009.04.003
  • Sox2
  • Sox9
  • Inner Ear
  • Otocyst
  • Hair Cells
  • Sensory Epithelia
  • Spiral Ganglion
  • Chemistry


Abstract The development of the inner ear involves complex processes of morphological changes, patterning and cell fate specification that are under strict molecular control. SOX2 and SOX9 are SOX family transcription factors that are involved in the regulation of one or more of these processes. Previous findings have shown early expression of SOX9 in the otic placode and vesicle at E8.5–E9.5. Here we describe in detail, the expression pattern of SOX9 in the developing mouse inner ear beyond the otocyst stage and compare it with that of SOX2 from E9.5 to E18.5 using double fluorescence immunohistochemistry. We found that SOX9 was widely expressed in the otic epithelium, periotic mesenchyme and cartilaginous otic capsule. SOX2 persistently marked the prosensory and sensory epithelia. During the development of the sensory epithelia, SOX2 was initially expressed in all prosensory regions and later in both the supporting and hair cells up to E15.5, when its expression in hair cells gradually diminished. SOX9 expression overlapped with that of SOX2 in the prosensory and sensory region until E14.5 when its expression was restricted to supporting cells. This initial overlap but subsequent differential expression of SOX2 and SOX9 in the sensory epithelia, suggest that SOX2 and SOX9 may have distinct roles in molecular pathways that direct cells towards different cell fates.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Expression of LHX3 and SOX2 during mouse inner ear...

on Gene expression patterns : GEP August 2007

Expression of LHX3 and SOX2 during mouse inner ear...

on Gene Expression Patterns Jan 01, 2007

Expression patterns of zebrafish sox11A, sox11B an...

on Mechanisms of development December 1999

Differential expression of Sox2 and Sox3 in neuron...

on The Journal of Comparative Neu... Aug 01, 2007
More articles like this..