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Dose-dependent effects of estradiol benzoate on 5-HT1Areceptor agonist action

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
796
Identifiers
DOI: 10.1016/s0006-8993(98)00238-8
Keywords
  • Lordosis Behavior
  • Female Rat
  • Hormone
  • Serotonin
  • 8-Oh-Dpat

Abstract

Abstract The lordosis-inhibiting effects of the 5-HT 1A receptor agonist, (±)8-hydroxy-2-(di- n-propylamino) tetralin (8-OH-DPAT), were examined in ovariectomized rats, hormone primed with 2.5, 7.5, or 25 μg estradiol benzoate plus 500 μg progesterone. 8-OH-DPAT (50, 100 or 200 ng per bilateral site) infused into the ventromedial nucleus of the hypothalamus (VMN), inhibited lordosis behavior in all hormone-treated conditions. However, animals primed with 2.5 μg estradiol benzoate were significantly more affected by the infusion than rats primed with 7.5 or 25 μg of the hormone. These findings strengthen prior speculations that 5-HT 1A receptor function is modulated by estrogen.

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