Abstract Emergency nurses have the opportunity to assist in the control of pneumococcal infections by recognizing and promoting treatment in the high-risk populations. When obtaining a history of prior trauma, the nurse should determine whether a splenectomy was done and whether the patient was given pneumococcal vaccine. Patients with known or suspected immunosuppression from any cause, including splenectomy, should be monitored closely for signs of infections. Emergency departments are often crowded with patients with unknown diagnoses, and patients with immunosuppression should be protected from contact with those who appear infected. By carefully managing those who are at risk of pneumococcal infection and providing the pneumococcal vaccine when indicated, the emergency care providers can contribute a great deal to the effort of reducing the mortality rate from sepsis.