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In this issue of Small GTPases

Small GTPases
Landes Bioscience
Publication Date
DOI: 10.4161/sgtp.23610
  • Editor'S Corner
  • Biology
  • Chemistry
  • Medicine

Abstract Small GTPases 1 Small GTPases 4:1, 1–2; January/February/March 2013; © 2013 Landes Bioscience EDITOR’S CAORNER EDITOR’S PREVIEW In this issue of Small GTPases Elaine L. Ellerton Landes Bioscience; Austin, TX USA Correspondence to: Elaine L. Ellerton; Email: [email protected] Submitted: 01/09/13 Accepted: 01/09/13 UpScaling Production of Myristoylated Arf6 pp. 3–8 One way to study the molecular mechanisms that the Arf family of GTPases uses to regulate intracellular traffic and organelle struc- ture requires in vitro biochemical assays. However, it is important to use a recombinant Arf protein that is in its cellular, myris- toylated form, a form that is difficult to purify. In this research paper, Padovani et al. have found an efficient way to produce highly pure N-myristoylated Arf6 on a large scale, thus paving a way to produce other myristoylated Arfs in the future (Fig. 1). The Making of Lysosome-Related Organelles with Rab32 and Rab38 pp. 16–22 Some cell types produce two similar organelles, lysosomes and lysosome-related organelles (LROs). But, what mechanism decides which organelle a certain cargo will be sent to? Bultema and Di Pietro discuss their recent research on a specific type of LRO, the melanosome, focusing on Rab32 and Rab38 and how these proteins are involved in the production of LROs and the trafficking of cargo to melanosomes. Cell Function According to Zizimin and Dock pp. 22–7 The Rho family of small GTPases plays an important role in many different cellular processes, such as migration, phagocy- tosis and proliferation. The switching of these GTPases from an active to an inactive state is controlled by the RhoGEF Zizimins, proteins from the Dock superfamily. In this commentary, Pakes et al. discuss the structure of Zizimin from an evolutionary stand- point and also compare them to Dock proteins. Understanding how these proteins function may provide insigh

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