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The role of MUC1 and MUC3 in the biology and prognosis of colorectal cancer

BioMed Central
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Abstract ral World Journal of Surgical Oncology ss BioMed Cent Open AcceResearch The role of MUC1 and MUC3 in the biology and prognosis of colorectal cancer Timothy J Duncan1, Nicholas FS Watson1,2, Ahmad H Al-Attar1, John H Scholefield2 and Lindy G Durrant*1 Address: 1Academic Department of Clinical Oncology, Institute of Immunology, Infections and Immunity, University of Nottingham, City Hospital, Nottingham, UK and 2Section of Gastrointestinal Surgery, Queen's Medical Centre, Nottingham, UK Email: Timothy J Duncan - [email protected]; Nicholas FS Watson - [email protected]; Ahmad H Al- Attar - [email protected]; John H Scholefield - [email protected]; Lindy G Durrant* - [email protected] * Corresponding author Abstract Background: MUC1 and MUC3 are from a large family of glycoproteins with an aberrant expression profile in various malignancies. Much interest has been focused on the role of these proteins in the development and progression of colorectal cancer; however, no previous studies have included the highly confounding variable of vascular invasion in their survival analysis. Using high throughput tissue microarray technology we assessed the prognostic value of MUC1 and MUC3 expression in the largest cohort of colorectal cancer patients to date. We propose that tumours lacking expression of MUC1 and MUC3 will be more likely to metastasise, due to previously observed loss of cell-cell adhesion, and this will therefore lead to more aggressive cancers with poorer prognosis. Methods: A tissue micro-array was prepared from tumour samples of 462 consecutive patients undergoing resection of a primary colorectal cancer. A comprehensive prospectively recorded data base with mean follow up of 75 months was collected and included common clinicopathological variables and disease specific survival. Immunohistochemical analysis of MUC1 and MUC3 expression was performed using antibodies NCL-MUC1 and 1143/B7

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