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The development of hepatic granulomas in 20 Krad irradiatedSchistosoma mansonicercaria vaccinated grivet monkeys (Cercopithecus aethiops aethiops)

Authors
Journal
Experimental Parasitology
0014-4894
Publisher
Elsevier
Publication Date
Volume
117
Issue
4
Identifiers
DOI: 10.1016/j.exppara.2007.05.006
Keywords
  • Cercopithecus Aethiops Aethiops
  • 20 Krad Irradiated Cercaria Vaccine
  • Granuloma
  • Worm Load
  • Egg Loads
Disciplines
  • Biology
  • Design
  • Medicine

Abstract

Abstract The absence of appropriate animal models is a challenge for those designing anti-schistosome vaccines. In order to observe the development of hepatic granulomata, 20 Krad irradiated cercaria vaccinated grivet monkeys ( Cercopithecus aethiops aethiops) were experimentally infected with Schistosoma mansoni. Most human clinical manifestations of schistosomiasis were noted in the infected monkeys. Intraperitonial immunization with 20 Krad irradiated cercaria resulted in a relatively less granulomatous reaction and lower egg mass ( P < 0.05) than in the controls. The mean total adult worms and egg production was also lower in the vaccinated group. This study underlines the significant role of irradiated cercariae vaccination on the establishment of female adults and consequent reduction of pathology in the grivet Cercopithecus aethiops aethiops.

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