Affordable Access

Publisher Website

Metalated fluoropyridines and fluoroquinolines as reactive intermediates: new ways for their regioselective generation

Authors
Journal
Tetrahedron
0040-4020
Publisher
Elsevier
Publication Date
Volume
50
Issue
4
Identifiers
DOI: 10.1016/s0040-4020(01)80824-3

Abstract

Abstract The mixture of lithium diisopropylamide and potassium tert-butoxide (“LIDA-KOR reagent”) is a powerful base which can be advantageously employed for the regioselective deprotonation of fluoropyridines and, in particular, 3-fluoroquinoline. A novel cyclization process was elaborated for the preparation of the latter product.

There are no comments yet on this publication. Be the first to share your thoughts.