Affordable Access

Publisher Website

Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
154
Issue
2
Identifiers
DOI: 10.1016/0014-5793(83)80188-4
Keywords
  • Human C4D
  • Sequence
  • Polymorphism
Disciplines
  • Biology

Abstract

Abstract The amino acid sequence of a segment of 106 residues of C4d has been determined by automated sequence analysis of fragments obtained by CNBr cleavage and enzymic digestion with trypsin. Polymorphism has been detected at 3 positions. Residues 9 and 12 are either valine and leucine or alanine and arginine, respectively. Residue 102 is either valine or arginine. When comparing the protein sequence with the nucleic, acid sequence [Carroll, M. and Porter, R.R. (1983) Proc. Natl. Acad. Sci. USA 80, in press] alanine or serine are found at position 98. These results may in part help to explain the inherited variants of human C4 seen on gel electrophoresis.

There are no comments yet on this publication. Be the first to share your thoughts.