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Co-administration of a commonly used Zimbabwean herbal treatment (African potato) does not alter the pharmacokinetics of lopinavir/ritonavir

Authors
Journal
International Journal of Infectious Diseases
1201-9712
Publisher
Elsevier
Volume
17
Issue
10
Identifiers
DOI: 10.1016/j.ijid.2013.02.017
Keywords
  • Herb–Drug Interactions
  • Hypoxis Obtusa
  • Pharmacokinetic Interactions
  • Herbal Medicines
Disciplines
  • Pharmacology

Abstract

Summary Objective African potato (Hypoxis obtusa) is commonly used in Sub-Saharan Africa as a complementary herbal remedy for HIV-infected patients. It is unknown whether or not co-administration of African potato alters the pharmacokinetics of protease inhibitor antiretrovirals. The objective of this study was to investigate the impact of the African potato on the steady-state pharmacokinetics of ritonavir-boosted lopinavir (LPV/r). Methods Sixteen adult volunteers were administered LPV/r 400/100mg twice a day for 14 days, followed by concomitant administration with African potato given once daily for 7 days. Lopinavir plasma exposure as estimated by the area under the concentration–time curve over the 12-h dosing interval (AUC0–12h, AUCτ) was determined on day 14 and again on day 21. Lopinavir in plasma was analyzed using a validated liquid chromatography with tandem mass spectrometry (LC-MS/MS) method. Steady-state AUCτ and the maximum concentration following dose administration (Cmax) were determined using non-compartmental methods using WinNonlin Professional version 5.2.1. Statistical analyses were performed using Stata version 12.1. Results Co-administration of African potato was not associated with any change in lopinavir AUCτ, Cmax, or Ctrough. Conclusions African potato when taken concomitantly with LPV/r is well-tolerated and not associated with clinically significant changes in lopinavir pharmacokinetics.

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