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Age-related decrease in the overall extent of perikaryal projections in rabbit spinal ganglion neurons

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
254
Issue
3
Identifiers
DOI: 10.1016/s0304-3940(98)00591-6
Keywords
  • Dorsal Root Ganglia
  • Sensory Neurons
  • Aging
  • Perikaryal Projections
  • Peripheral Neuroglia
  • Oryctolagus Cuniculus

Abstract

Abstract The overall extent of the perikaryal projections of sensory neurons from spinal ganglia of young adult and aged rabbits was estimated by a stereological method using the electron microscope. The extent of perikaryal projections was significantly smaller in the aged animals. This age-related decrease did not seem to depend on factors intrinsic to the neuron, but on the absence of a satellite cell covering over extensive portions of the nerve cell body surface. This decrease may influence the organization of the subplasmalemmal cytoskeleton, metabolic exchange between the nerve cell body and its environment and perhaps also neuronal metabolism.

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