Affordable Access

Publisher Website

A method for the chromatographic resolution of tetrahydropyran-2-ones

Authors
Journal
Tetrahedron
0040-4020
Publisher
Elsevier
Publication Date
Volume
47
Issue
47
Identifiers
DOI: 10.1016/s0040-4020(01)80729-8
Keywords
  • Chromatographic Resolution
  • Tetrahydropyran-2-Ones
  • Lactones
  • Ortholactones
  • 1
  • 5
  • 7-Trioxaspiro[5
  • 5]Undecane

Abstract

Abstract The spirocyclic ortholactones prepared from certain tetrahydropyran-2-ones (valerolactones) and (1R)-1-phenylpropan-1,3-diol are readily separable by flash chromatography on silica gel. Hydrolysis of the resolved ortholactones then provides the pure homochiral lactones.

There are no comments yet on this publication. Be the first to share your thoughts.