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3H-apomorphine interactions with dopamine receptors in calf brain

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
49
Issue
3
Identifiers
DOI: 10.1016/0014-2999(78)90105-x
Keywords
  • 3H-Apomorphine Binding
  • Dopamine Receptor
  • 3H-Haloperidol Binding
  • Neuroleptic
  • 3H-Dopamine Binding

Abstract

Abstract 3H-apomorphine binds to membranes from areas of the corpus striatum and limbic system of calf brain saturable and with a drug specificity indicating that it labels dopamine receptors. In terms of drug specificity, log-logit displacement curve slopes and number of binding sites, 3H-apomorphine interacts with receptors in a manner more like 3H-dopamine than 3H-haloperidol. These properties of 3H-apomorphine binding are those of an apparently “pure” agonist in contrast to the partial agonist effects of apomorphine upon the dopamine-sensitive adenylate cyclase.

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