Objective This study evaluated the ability of a resin-based system (Resilon/Epiphany) and gutta-percha/sealer with warm vertical or cold lateral compaction to prevent coronal leakage. Study design A polymicrobial suspension in a dual-chamber model was used. Seventy extracted maxillary incisors were prepared, divided into 4 groups, and obturated: Group 1, lateral compaction/gutta-percha/AH Plus; Group 2, lateral compaction/Resilon; Group 3, continuous wave compaction/gutta-percha/AH Plus; Group 4, continuous wave compaction/Resilon. Upper chambers held a mixed suspension of endodontic pathogens. Apices were suspended in the lower chambers. Leakage was determined daily for 40 days and evaluated for turbidity. Data were analyzed using survival analysis; log-rank test was used to analyze differences in time to leakage. Results Median time to leakage: 16, 15, 11, and 25 days for Groups 1 to 4 respectively ( P = .93, log-rank test). Conclusion No difference in time to leakage among the 4 treatment groups existed.