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Insulin Receptor Knock-Out Mice

Authors
Journal
Trends in Endocrinology and Metabolism
1043-2760
Publisher
Elsevier
Publication Date
Volume
8
Issue
3
Identifiers
DOI: 10.1016/s1043-2760(97)00031-3
Disciplines
  • Medicine

Abstract

Abstract Targeted mutagenesis of the insulin receptor gene in mice has yielded unexpected results. This article reviews recent findings and analyzes this animal model can further our understanding of the mechanism of insulin action and its impairment in non-insulin-dependent diabetes mellitus is analyzed. (Trends Endocrinol Metab 1997;8:101–104). Published 1997 by Elsevier Science Inc.

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