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Preparation of electrospun poly(l-lactide-co-caprolactone-co-glycolide)/phospholipid polymer/rapamycin blended fibers for vascular application

Authors
Journal
Current Applied Physics
1567-1739
Publisher
Elsevier
Publication Date
Volume
9
Issue
4
Identifiers
DOI: 10.1016/j.cap.2009.06.001
Keywords
  • Poly(L-Lactide-Co-Caprolactone-Co-Glycolide)
  • Phospholipid Polymer
  • Rapamycin
  • Electrospinning
  • Artificial Vessels
Disciplines
  • Biology
  • Chemistry
  • Engineering

Abstract

Abstract Nanopores generated from the gap among electrospun nanofibers can provide vascular tissues with oxygen, nutrients, and growth factors. Here, we report the first fabrication of poly( l-lactide- co-caprolactone- co-glycolide) (PLCG) electrospun nanofibers. A water-soluble amphiphilic copolymer bearing phosphorylcholine groups (PMB30W) and an antiproliferative (rapamycin) were incorporated into PLCG by solvent blending and subsequent electrospinning. The nanostructure of the electrospun PLCG/PMB30W/rapamycin blended fibers was stable during incubation in phosphate-buffered saline without addition of chemical crosslinkers. Amphiphilic characteristics of PMB30W and hydrophobic nature of rapamycin could make the electrospun PLCG/PMB30W/rapamycin blended fibers stable under a physiologic condition. The electrospun PLCG/PMB30W/rapamycin blended fibers may be preferable for vascular prostheses and tissue-engineered vascular grafts.

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