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Spermine prevent iron accumulation and depress lipofuscin accumulation in cultured myocardial cells

Authors
Journal
Free Radical Biology and Medicine
0891-5849
Publisher
Elsevier
Publication Date
Volume
21
Issue
3
Identifiers
DOI: 10.1016/0891-5849(96)00038-x
Keywords
  • Spermine
  • Deferoaxamine
  • Antioxidant
  • Fenton Reaction
  • Myocyte
  • Aging
  • Lipofuscin
  • Oxygen Radicals
Disciplines
  • Biology
  • Medicine

Abstract

Abstract The present work demonstrates that spermine prevents aging in cultured myocytes exposed to oxidative stress. It is found that physiological levels of spermine reduce lipofuscin accumulation with 20%, and that the antioxidative effect compares with vitamin E. By autometallography we also demonstrate that spermine prevent accumulation of free iron in the myocytes, probably by acting as a chelating agent. The effect compares to that of deferoxamine. These data provide additional insight into the antioxidative mechanism of spermine, and suggest that spermine may prevent diseases related to the Fenton reaction, as well as retard aging reactions.

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