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4α-Methylated steroids with cytotoxic activity from the soft coral Litophyton mollis

Authors
  • Zovko Končić, Marijana
  • Ioannou, Efstathia
  • Sawadogo, Wamtinga Richard
  • Abdel-razik, Ayman F.
  • Vagias, Constantinos
  • Marc Diederich
  • Roussis, Vassilios
Type
Published Article
Journal
Steroids
Publisher
Elsevier
Publication Date
Nov 24, 2016
Volume
115
Identifiers
DOI: 10.1016/j.steroids.2016.08.017
Source
LBMCC
Keywords
License
Green

Abstract

Seven new (1–3, 5 and 8–10) and three previously reported (4, 6 and 7) 4α-methylated steroids were isolated from the organic extract of the gorgonian Litophyton mollis. The structures and the relative configurations of the isolated natural products were determined on the basis of extensive analyses of their NMR and MS data. Metabolites 1 and 5–8 exhibited cytotoxic activity against K562 human chronic myelogenous leukemia cells with IC 50 values below 10 μM, while at the same time displaying low toxicity against …

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