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Fructose 2,6-bisphosphate induces irreversible transitions in cell-free extracts of rat liver

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
390
Issue
2
Identifiers
DOI: 10.1016/0014-5793(96)00664-3
Keywords
  • Bistability
  • Glycolysis
  • Hysteresis
  • Irreversible Transition
  • Nonlinear Dynamics
  • Phosphofructokinase/Fructose-1
  • 6-Bisphosphatase Cycle

Abstract

Abstract The effect of fructose 2,6-bisphosphate on the dynamics of the 6-phosphofructo-1-kinase/fructose-1,6-bisphos-phatase cycle is investigated in a cell-free extract of rat liver under steady-state conditions. Bistability emerges on the basis of the reciprocal allosteric modulation of 6-phosphofructo-1-kinase and fructose-1,6-bisphosphatase. Under conditions of bistability fructose 2,6-bisphosphate may cause transitions between alternative steady states. However, in contrast to what is frequently observed in bistable systems, within a broad range of experimental conditions these transitions proceed irreversibly from states with high ATP to states characterized by low ATP.

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