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β-Cyclodextrin interacts with the Alzheimer amyloid β-A4 peptide

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
341
Identifiers
DOI: 10.1016/0014-5793(94)80467-2
Keywords
  • Amyloid
  • A4 Peptide
  • Alzheimer'S Disease
  • β-Cyclodextrin
  • Electrospray Ionisation Mass Spectrometry
  • Fibrillisation

Abstract

Abstract Electrospray ionisation mass spectrometry has been used to show that the synthetic 40 amino acid β-amyloid peptide (β1-40) interacts with the cyclic oligosaccharide β-cyclodextrin. This interaction, presumably with the hydrophobic aromatic moieties on the peptide, has been shown to diminish substantially the neurotoxic effects of β1-40 in a cell line.

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