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BIOMARKER DISCOVERY THROUGH SECRETOME ANALYSIS OF PARKINSON'S DISEASE MODEL CELL LINES

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  • Medicine

Abstract

Abstract Form Abstract form - Benzon Symposium 56 – Functional and Pathogenic Protein Aggregation – Copenhagen 2009 Presenting author: Stensballe, Allan Institution: Aalborg University Department: Department of Biotechnology, Chemistry and Environmental Engineering Street & Number: Sohngaardsholmsvej 49 City & Zip code: 9000 Aalborg Country: Denmark Phone: (incl. Country code) + 45 6160 8786 Fax: (incl. Country code) +45 ?? ?? ?? ?? E-Mail: [email protected] Please indicate if you can accept to be selected for an oral presentation: YES / NO BIOMARKER DISCOVERY THROUGH SECRETOME ANALYSIS OF PARKINSON'S DISEASE MODEL CELL LINES Stensballe A 1 , Otzen D 2 & Knudsen AD 1 ; Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Denmark, 2 Interdisciplinary Nanoscience Centre, University of Aarhus, Denmark E-mail: [email protected] Parkinson's disease (PD), a chronic degenerative brain disease, is characterized by a loss of dopiminergic neurons in the substantia nigra area of the brain and the abnormal presence of ubiquitinated cytoplasmic inclusions called Lewy bodies in affected cells. Parkinson's disease can be diagnosed precisely by post-mortem analysis of the affected areas of the brain whereas early clinical diagnosis of PD may be based on the patient's medical history and neurological examinations before a symptom calming treatment can be implemented. Thus, the interest in finding early biomarkers for this neurodegenerative diseases before clinical symptoms arise is great. Cerebrospinal fluid (CSF) is the most relevant biological fluid for biomarker study because CSF has direct contact with the extra cellular space in the brain. The CSF Proteome is, however, extremely complex and patient samples are often available only in small volume whereby direct analysis by specific PD biomarkers is a major analytical challenge. Alternatively, Conditioned

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