Affordable Access

Publisher Website

Benefits and harms of perioperative beta-blockade

Authors
Journal
Best Practice & Research Clinical Anaesthesiology
1521-6896
Publisher
Elsevier
Publication Date
Volume
20
Issue
2
Identifiers
DOI: 10.1016/j.bpa.2005.10.006
Keywords
  • Beta-Blockers
  • Adrenergic
  • Perioperative Care
  • Surgery
  • Perioperative Procedures
  • Surgical Procedures
  • Cardiac Surgical Procedures
  • Postoperative
  • Mortality
  • Myocardial Infarction
Disciplines
  • Medicine

Abstract

Cardiac events in patients undergoing surgery may have serious consequences for both short- and long-term postoperative prognosis. Recently conducted trials have not demonstrated beneficial effects of perioperative beta-blockade, although originally small trials with methodological flaws did suggest this. We evaluate the evidence for using perioperative beta-blockade in both cardiac and non-cardiac surgery, and conclude that there is no statistically significant effect on mortality and insufficient evidence for a reduction of the incidence of mycocardial infarction in meta-analyses of all randomized trials. However, confidence intervals of the intervention effects in the meta-analyses are wide, leaving room for both benefits and harms. The largest observational study performed suggests that perioperative beta-blockade is associated with higher mortality in patients with low cardiac risk or diabetes, and with lower mortality in patients with high cardiac risk undergoing non-cardiac surgery. Larger randomized trials are needed to determine dosage, optimal duration, and safety of therapy, and to identify populations in whom—and how—perioperative beta-blockade may be beneficial.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Benefits and harms of perioperative beta-blockade.

on Best practice & research. Clin... June 2006

Perioperative beta-blockade.

on BJA British Journal of Anaesth... July 2001

Perioperative Beta blockade.

on Clinics in colon and rectal su... September 2013

Perioperative beta blockade.

on The Lancet Sep 27, 2008
More articles like this..