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Acute toxicity of alkyl (1-phenylsulfonyl)cycloalsane-carboxylates to Daphnia magna and quantitative structure—Activity relationships

Authors
Journal
Chemosphere
0045-6535
Publisher
Elsevier
Publication Date
Volume
31
Issue
2
Identifiers
DOI: 10.1016/0045-6535(95)00129-v
Disciplines
  • Biology

Abstract

Abstract Acute toxicities of alkyl (1-phenylsulfonyl)cycloalkane-carboxylates to Daphnia magna are correlated by linear solvation energy relationships. The biological response, as a function of toxicant properties, is given by log 1 LC 50 ( mol/ L) = 2.08(0.24) + 1.90(0.11) V 1 100 − 1.20(0.24)β n=22 r=0.964 sd=0.085 log 1 EC 50 ( mol/ L) = 2.45(0.27) + 1.91(0.13) V 1 100 − 1.24(0.27)β n=22 r=0.955 sd=0.096> where V 1 is the intrinsic solute molecular volume, β is the solvatochromic parameter that measures hydrogen bond basicity of the toxicant. The predicted values with above two equations are close to observed ones. The above equations also provide quantitative information on the factors affecting toxicity of alkyl (1-phenylsulfonyl) cycloalkane-carboxylates.

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