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Transient Phenomena in Gene Expression after Induction of Transcription

Authors
Journal
PLoS ONE
1932-6203
Publisher
Public Library of Science
Publication Date
Volume
7
Issue
4
Identifiers
DOI: 10.1371/journal.pone.0035044
Keywords
  • Research Article
  • Biology
  • Biochemistry
  • Proteins
  • Protein Synthesis
  • Biophysics
  • Nucleic Acids
  • Rna
  • Rna Stability
  • Biophysics Simulations
  • Biophysics Theory
  • Computational Biology
  • Systems Biology
  • Molecular Cell Biology
  • Gene Expression
  • Theoretical Biology
  • Mathematics
  • Probability Theory
  • Stochastic Processes
  • Physics
  • Statistical Mechanics
Disciplines
  • Biology

Abstract

When transcription of a gene is induced by a stimulus, the number of its mRNA molecules changes with time. Here we discuss how this time evolution depends on the shape of the mRNA lifetime distribution. Analysis of the statistical properties of this change reveals transient effects on polysomes, ribosomal profiles, and rate of protein synthesis. Our studies reveal that transient phenomena in gene expression strongly depend on the specific form of the mRNA lifetime distribution.

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