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Impaired tolerance to repetitive hypoxia in hippocampal slices of Cu,Zn superoxide dismutase transgenic mice

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
276
Issue
2
Identifiers
DOI: 10.1016/s0304-3940(99)00808-3
Keywords
  • Amyotrophic Lateral Sclerosis
  • Hypoxic Tolerance
  • Chemical Preconditioning
  • Hippocampal Slice
  • C57B6Sjl
  • Tgn(Sod1-G93A)1Gur Mice

Abstract

Abstract Energy metabolism is impaired in the Cu,Zn superoxide dismutase transgenic mouse model of amyotrophic lateral sclerosis. The goal was to investigate tolerance against single and repetitive hypoxia in C57B6SJL-TgN(SOD1-G93A)1GUR mice (G93A mice). Posthypoxic recovery (15 min hypoxia, 45 min recovery) of population spike amplitude in hippocampal region CA1 was 38±29% (mean±SD) in controls and 67±41% (ns) in G93A mice at day 40. Upon in vivo pretreatment with 20 mg/kg 3-nitropropionate posthypoxic recovery increased to 82±32% ( P<0.01) in controls and decreased to 35±33% in G93A mice ( P<0.05 to pretreated controls). Results at day 80 and 110 were similar. We conclude that G93A mice show a long-lasting impairment to sustain repetitive hypoxic episodes whereas tolerance to a single hypoxic episode is comparable to controls.

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