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Détermination d'un index prédictif de la preeclampsie en préconceptionnel et propositions thérapeutiques de prévention primaire

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  • Preeclampsia
  • Hypertension
  • Predictive Index
  • Thrombophilia
  • Prenatal Care
  • Life Sciences :: Anatomy (Cytology
  • Histology
  • Embryology...) & Physiology [F02]
  • Sciences Du Vivant :: Anatomie (Cytologie
  • Histologie
  • Embryologie...) & Physiologie [F02]
  • Human Health Sciences :: Reproductive Medicine (Gynecology
  • Andrology
  • Obstetrics) [D24]
  • Sciences De La Santé Humaine :: Médecine De La Reproduction (Gynécologie
  • Andrologie
  • Obstétrique) [D24]
  • Medicine


Objective To derive a prediction index based on the most salient history, laboratory and clinical parameters for identifying women at high risk of developing preeclampsia (PE) and to suggest a primary prevention. Material and method Non-pregnant women with a history of PE (n =101) were compared to non-pregnant parous women with a history of one or more successful normotensive pregnancies (n =50) but with comparable age, gestation and parity profiles. The parameters included history and clinical examination; laboratory studies (hemostasis, coagulation, vitamins); and morphological and functional tests (cardiovascular and renal functions). Stepwise logistic regression analysis was applied to develop a three step PE prediction index based on the most discriminant parameters. Strategies to prevent PE in the high-risk group are described. Results Identification of women at high risk of PE can be done efficiently (88% sensitivity and specificity) using a predictive index based on a simple history, laboratory, clinical and functional information. Stategies to prevent PE in our high-risk group have given encouraging results during next pregnancy. Conclusion Our study gives a predictive index of PE outside of pregnancy and possibilities to do a primary prevention.

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