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Identification ofN,N-dimethyltryptamine as the product of anin vitroenzymic methylation

Authors
Journal
Analytical Biochemistry
0003-2697
Publisher
Elsevier
Publication Date
Volume
47
Issue
1
Identifiers
DOI: 10.1016/0003-2697(72)90296-5
Disciplines
  • Biology

Abstract

Abstract Thin-layer chromatography, reverse isotope dilution assay, and combined gas-liquid chromatography-mass spectrometry have demonstrated that an enzyme obtained from human lung catalyzes the in vitro methylation of N-methyltryptamine by S-adenosylmethionine to form N,N-dimethyltryptamine. Isolation of the product of the enzymic reaction and its identification were facilitated by use of carbon-14 and deuterium labeling.

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