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SH Domains

Authors
Publisher
Elsevier Inc.
Identifiers
DOI: 10.1016/b978-0-12-374984-0.01413-3
Keywords
  • Phosphotyrosine
  • Protein Module
  • Protein–Protein Interaction
  • Signal Transduction
  • Src Homology
  • Tyrosine Kinase
Disciplines
  • Biology

Abstract

Abstract The Src homology (SH) domains are protein modules with defined structures and protein–protein interaction function that are found in Src family kinases and also in many other intracellular signal transduction proteins, including, for example, receptor protein tyrosine kinases, phospholipase C-gamma, and the Ras GTPase-activating protein. The SH domains exemplify protein–protein interaction domains, which like their cognate recognition motifs are modular in nature. Their widespread occurrence and conserved molecular functions, even in the context of proteins with distinct enzymatic or biological properties, has led to the concept of ‘protein recognition codes’.

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