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Stress reactivity in young marmosets (Callithrix geoffroyi): Ontogeny, stability, and lack of concordance among co-twins

Authors
Journal
Hormones and Behavior
0018-506X
Publisher
Elsevier
Volume
61
Issue
2
Identifiers
DOI: 10.1016/j.yhbeh.2011.12.006
Keywords
  • Stress Reactivity
  • Trait
  • Urinary Cortisol
  • Stability
  • Marmoset
  • Area Under The Curve

Abstract

Abstract Variation in response styles in the hypothalamic–pituitary–adrenal (HPA) axis are known to be predictors of short- and long-term health outcomes. The nature of HPA responses to stressors changes with developmental stage, and some components of the stress response exhibit long-term individual consistency (i.e., are trait-like) while others are transient or variable (i.e., state-like). Here we evaluated the response of marmoset monkeys (Callithrix geoffroyi) to a standardized social stressor (social separation and exposure to a novel environment) at three different stages of development: juvenile, subadult, and young adult. We monitored levels of urinary cortisol (CORT), and derived multiple measures of HPA activity: Baseline CORT, CORT reactivity, CORT Area Under the Curve (AUC), and CORT regulation. Juvenile marmosets exhibited the most dramatic stress response, had higher AUCs, and tended to show poorer regulation. While baseline CORT and CORT regulation were not consistent within an individual across age, CORT reactivity and measures of AUC were highly correlated across time; i.e., individuals with high stress reactivity and AUC as juveniles also had high measures as subadults and adults, and vice-versa. Marmoset co-twins did not exhibit similar patterns of stress reactivity. These data suggest that regardless of the source of variation in stress response styles in marmosets, individually-distinctive patterns are established by six months of age, and persist for at least a year throughout different phases of marmoset life history.

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